Back to results
US 7,884,136 B2Granted
Modified-release formulations of a bupropion salt
AssigneeBiovail Laboratories International S.R.L.
InventorsWerner Oberegger, Fang Zhou, Paul Maes, Stefano Turchetta, Graham Jackson, Pietro Massardo, Mohammad Ashty Saleh
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
Claims4
A composition, comprising at least one pharmaceutically acceptable excipient;
- and two or more of the following crystalline compounds:
- (i) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having characteristic peaks at about 6.70 °2Theta, about 12.51 °2Theta, about 19.60 °2Theta, about 22.93 °2Theta and about 26.11 °2Theta;
- (ii) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having characteristic peaks at about 6.53 °2Theta, about 13.03 °2Theta, about 15.91 °2Theta, about 16.52 °2Theta and about 23.11 °2Theta;
- and
- (iii) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having characteristic peaks at about 8.06 °2Theta, about 12.28 °2Theta, about 16.00 °2Theta, about 18.07 °2Theta and about 25.12 °2Theta.
5 more elements
A composition, comprising at least one pharmaceutically acceptable excipient;
- and two or more of the following crystalline compounds:
- (i) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having five or more characteristic peaks selected from the group consisting of about 6.70 °2Theta, about 12.51 °2Theta, about 13.83 °2Theta, about 19.60 °2Theta, about 22.93 °2Theta, about 23.98 °2Theta, about 24.76 °2Theta, about 25.51 °2Theta, about 26.11 °2Theta and about 32.70 °2Theta;
- (ii) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having five or more characteristic peaks selected from group consisting of about 6.53 °2Theta, about 13.03 °2Theta, about 15.91 °2Theta, about 16.52 °2Theta, about 21.95 °2Theta, about 23.11 °2Theta, about 25.83 °2Theta, about 26.83 °2Theta, about 28.81 °2Theta and about 32.42 °2Theta;
- and
- (iii) a crystalline compound of the formula:
- exhibiting an X-ray powder diffraction pattern with an X-ray source of Cu/30 kV and having five or more characteristic peaks selected from the group consisting of about 8.06 °2Theta, about 12.28 °2Theta, about 16.00 °2Theta, about 18.07 °2Theta, about 19.67 °2Theta, about 23.42 °2Theta, about 24.24 °2Theta, about 25.12 °2Theta, about 28.99 °2Theta and about 29.66 °2Theta.
5 more elements
Dependencies are inferred from the claim text.