US 7,884,129 B2 · Composition comprising the alcohol compound isolated from the extract of cucurbitaceae family plant having anti-adipogenic and anti-obesity activity

Abstract

The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

Claims5

Dependent claims

A method of treatment to induce an anti-obesity effect comprising the step of administering an effective amount of dehyrodiconiferyl alcohol (DHCA) of formula (1a) into a subject in need thereof,

wherein the anti-obesity effect is selected from the group consisting of (i) inhibiting adipocyte differentiation, (ii) inhibiting triglyceride synthesis, (iii) activating PPAR alpha and (iv) reducing body weight.

Dependencies are inferred from the claim text.

Facts

Application

12/124,131Filed 20 May 2008 · continuation in part

Priority

KR 10-2003-00872753 Dec 2003

Published

US 2008/0280976 A113 Nov 2008

Granted

8 Feb 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 36/42
Magnoliopsida: cucurbitaceae
A23L 33/105
Using additives: plant extracts, their artificial duplicates or their derivatives
A61K 31/343
Having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide: condensed with a carbocyclic ring, e.g. coumaran,…
A61P 3/00
Drugs for disorders of the metabolism

Family

PCT/KR2004/003169Parent of this continuation-in-part · filed 3 Dec 2004

US 2008/0280976 A1Pre-grant publication · published 13 Nov 2008

Application10/581,576Parent of this continuation-in-part

US 2007/0110834 A1Published application

US 7,884,129 B2This patent

From the US filing history. Foreign family members aren’t listed.

Composition comprising the alcohol compound isolated from the extract of cucurbitaceae family plant having anti-adipogenic and anti-obesity activity

Life of this patent

Composition comprising the alcohol compound isolated from the extract of cucurbitaceae family plant having anti-adipogenic and anti-obesity activity

Life of this patent

Abstract

Claims5