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US 7,883,843 B2Granted
Hepatitis virus core proteins as vaccine platforms and methods of use thereof
AssigneeVaccine Research Institute of San Diego
InventorsDavid R. Milich, Jean-Noel Billaud
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Abstract
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.
Claims6
A method for producing an immune response, comprising
- a) providing:
- a composition comprising one of:
- 1) a hybrid particle comprising a fusion protein comprising a rodent hepadnavirus core antigen and a heterologous antigen, wherein said hybrid particle is a hybrid ground squirrel hepadnavirus particle that assembles satisfactorily of Table 15, or woodchuck hepadnavirus particle that assembles satisfactorily of Table 11, Table 12, Table 13, Table 15, or Table 16, and
- 2) an expression vector encoding said fusion protein;
- and
- b) administering said composition to an animal under conditions such that an immune response is generated to said heterologous antigen.
3 more elements
Dependencies are inferred from the claim text.