Continuous granulating and drying apparatus including measurement units
AssigneeCollette NV
InventorsMichel Simon Waldron, Trevor Gordon Page, Tomas Vermeire
Life of this patent
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Abstract
A continuous granulating and drying apparatus includes a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.
Claims10
A continuous granulating and drying apparatus for pharmaceutical products, comprising a granulator and a dryer, the granulator including a granulation chamber having a first end with an inlet for powder material and a binder feed port, and a second end with an outlet for granulated product, the dryer having a granulated product supply conduit and a product discharge conduit, wherein said apparatus includes a plurality of measurement units,
- wherein said dryer is a fluid bed dryer,
- wherein said fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other, each processing compartment having a product inlet and a product outlet, the fluid bed dryer further comprising a bed plate having openings for fluidizing gas and being arranged above a gas inlet, a gas outlet, a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively,
- wherein the outlet for granulated product of the granulation chamber has a substantially larger cross-sectional dimension than the granulated product supply conduit of the fluid bed dryer,
- wherein the outlet for granulated product is connected to the granulated product supply conduit of the inlet of the dryer by means of a transition piece comprising a housing having an inlet end mating the outlet for granulated product and an outlet end mating the product supply conduit,
- wherein the housing is provided with a flexible liner having a first end and a second end that has a substantially smaller cross-sectional dimension than the first end, the circumference of the flexible liner being connected in a fluid tight manner with the housing at each end of the flexible liner, so that an annular enclosure is formed between the flexible liner and the housing, and
- wherein the annular enclosure communicates with a control fluid connection.
A continuous granulating and drying apparatus for pharmaceutical products, comprising a granulator and a dryer, the granulator including a granulation chamber having a first end with an inlet for powder material and a binder feed port, and a second end with an outlet for granulated product, the dryer having a granulated product supply conduit and a product discharge conduit, wherein said apparatus includes a plurality of measurement units,
- wherein the outlet for granulated product of the granulation chamber has a substantially larger cross-sectional dimension than the granulated product supply conduit of the fluid bed dryer, wherein the outlet for granulated product is connected to the granulated product supply conduit of the inlet of the dryer by means of a transition piece comprising a housing having an inlet end mating the outlet for granulated product and an outlet end mating the product supply conduit, wherein the housing is provided with a flexible liner having a first end and a second end that has a substantially smaller cross-sectional dimension than the first end, the circumference of the flexible liner being connected in a fluid tight manner with the housing at each end of the flexible liner, so that an annular enclosure is formed between the flexible liner and the housing, and wherein the annular enclosure communicates with a control fluid connection.
Dependencies are inferred from the claim text.