Aniline derivatives

A compound represented by the formula (A):

• wherein
• X is a carbon atom;
• M is selected from the group consisting of a hydrogen atom, a halogeno group, a lower alkyl group optionally having substituent(s), —(CH2)mORa, —CH(ORa)(ORa′), —(CH2)mNRaRa′, —(CH2)mCO2Ra, —(CH2)mCONRaRa′, —CH═CHCO2Ra, —(CH2)mCOCO2Ra, and —(CH2)mPO(ORa)(ORa′)
• wherein
• m is an integer of 0 to 2, and
• Ra and Ra′ are each independently selected from the group consisting of a hydrogen atom and a lower alkyl group;
• Z is selected from the group consisting of a single bond, —CH(Rb)—, —CH(Rb)—CH(Rb′)—, —CH═CH—, and —C(O)—
• wherein
• Rb and Rb′ are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a nitro group, a cyano group, an ammonium group, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and -QR10
• wherein
• Q is selected from the group consisting of —O—, —S(O)p—, —S(O)pO—, —NH—, —NR11-, —C(═O)—, —C(═O)O—, —C(═O)NH—, —C(═O)NR11-, —S(O)pNH—, —S(O)pNR11-, —NHC(═O)—, —NR11C(═O)—, —NHS(O)p—, and —R11S(O)p—
• wherein
• p is an integer of 0 to 2, and
• R10 and R11 are each independently selected from the group consisting of a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and an acyl group, or R10 and R11 are optionally bonded to form a ring;
• B is selected from the group consisting of a hydrogen atom, a lower alkyl group optionally having substituent(s), and a group represented by the formula (D):
• wherein
• ring b is selected from the group consisting of a cycloalkyl group, a heterocyclic group, and an aryl group, and
• R4 and R5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a cyano group, a nitro group, an ammonium group, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), and -Q′R20
• wherein
• Q′ is selected from the group consisting of —O—, —S(O)p′—, —S(O)p′O—, —NH—, —NR21-, —C(═O)—, —C(═O)O—, —C(═O)NH—, —C(═O)NR21-, —S(O)p′NH—, —S(O)p′NR21-, —NHC(═O)—, —NR21C(═O)—, —NHS(O)p′—, and —NR21S(O)p′—
• wherein
• p′ is an integer of 0 to 2, and
• R20 and R21 are each independently selected from the group consisting of a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s), an alkynyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), a heterocyclic group optionally having substituent(s), an aryl group optionally having substituent(s), a cycloalkylalkyl group optionally having substituent(s), a heterocyclylalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), an acyl group, and a hydroxyl group, or R20 and R21 are optionally bonded to form a ring;
• R3 is selected from the group consisting of a hydrogen atom, a lower alkyl group optionally having substituent(s) and an aryl group optionally having substituent(s), or R3 is optionally bonded to B to form a nitrogen-containing 5- or 6-membered ring, wherein said nitrogen-containing 5- or 6- membered ring optionally further contains a heteroatom in the ring in addition to the nitrogen atom, and wherein said nitrogen-containing 5- or 6-membered ring is optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, an alkylamino group, an acyl group, a heterocyclic group optionally having substituent(s), and an aryl group optionally having substituent(s);
• Y is —C(O)— or —SO2—;
• R1a is a lower alkyl group optionally having substituent(s) or an aryl group optionally having substituent(s), and R1a′ is a hydrogen atom;
• or R1a and R1a′ are bonded to form a 3- to 6-membered ring, wherein said 3- to 6-membered ring optionally contains a heteroatom in the ring and optionally having substituent(s),
• R2 is a hydrogen atom or a lower alkyl group, or R1a (or R1a′) and R2 are optionally bonded to form a 5- or 6-membered ring, wherein said 5- or 6- membered ring optionally contains a heteroatom in the ring and optionally having substituent(s);
• n is 0 or 1;
• and
• R6 and R6′ are each independently selected from the group consisting of a hydrogen atom, a lower alkyl group optionally having substituent(s), an amino group, an aminoalkyl group, and an alkoxy group;
• or a pharmaceutically acceptable salt thereof.