Therapeutic or prophylactic agent for multiple sclerosis
AssigneeToray Industries, Inc.
InventorsKenichi Hayashi, Mie Kaino, Hiroyuki Meguro
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Abstract
A therapeutic or prophylactic agent for multiple sclerosis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for multiple sclerosis according to the present invention shows the excellent absorbability and in vivo stability when orally administered, and exhibits high therapeutic or prophylactic effects.
Claims4
A method for treating multiple sclerosis comprising administering an effective amount of (a) a compound of Formula (I) to a subject in need thereof:
- wherein
- R1 represents hydrogen or C1-C5 alkyl:
- X independently represents fluoro, chloro, bromo, iodo or C1-C3 alkyl;
- V represents —CH═CH— or —C≡C—;
- Y represents Formula (II) or Formula (III):
- wherein
- R2 represents C1-C5 alkyl or C1-C3 alkoxy;
- R3 represents hydrogen or C1-C5 alkyl;
- m represents an integer of 0 to 3;
- n represents 0 or 1;
- p represents an integer of 0 to 2;
- W represents —O— or —N(R4)—
- wherein
- R4 represents hydrogen, C1-C5 alkyl, C3-C6 alkenyl, phenyl, benzyl, benzyl substituted with one or two R5s, tetrahydropyranyl, —(CH2)q—O—CH3, pyridylmethyl, —(CH2)q—CN, C4-C7 cycloalkymethyl or thiazol-4-ylmethyl;
- R5 represents hydroxyl or C1-C3 alkoxy;
- and
- q represents an integer of 1 to 3;
- or (b) a pharmaceutically acceptable salt of the compound of said Formula (I).
Dependencies are inferred from the claim text.