Stabilized sulforaphane
AssigneePharmAgra Labs, Inc.
InventorsIdo Dov Dagan, Albert Roger Frisbee, Peter Wyatt Newsome, Michel Pierre Baudet
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Abstract
A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog thereof, and the cyclodextrin.
Claims33
A method of stabilizing sulforaphane, or an analog thereof, the method comprising:
- contacting sulforaphane or an analog of sulforaphane selected from one or more of 6 isothiocyanato-2-hexanone, exo-2-acetyl-6-isothiocyanatonorbornane, exo-2-isothiocyanato-6-methylsulfonylnorbornane, 6-isothiocyanato-2-hexanol, 1-isothiocyanato-4-dimethylphosphonylbutane, exo-2-(1′-hydroxyethyl)-5-isothiocyanatonorborane, exo-2-acetyl-5-isothiocyanoatonorbornane, 1-isothiocyanato-5-methylsulfonylpentane, and cis- or trans-3-(methylsulfonyl)-cyclohexylmethyl-isothiocyanate, and mixtures thereof, and at least one cyclodextrin to form a complex between the sulforaphane, or analog of sulforaphane, and the at least one cyclodextrin.
A composition comprising a complex of sulforaphane and a cyclodextrin.
A composition comprising a complex of an analog of sulforaphane and a cyclodextrin, wherein the analog of sulforaphane is selected from the group consisting of 6-isothiocyanato-2-hexanone, exo-2-acetyl-6-isothiocyanatonorbornane, exo-2-isothiocyanoat-6-methylsulfonylnorbornane, 6-isothiocyanato-2-hexanol, 1-isothiocyanato-4-dimethylphosphonylbutane, exo-2-(1′-hydroxyethyl)-5-isothiocyanatonorborane, exo-2-acetyl-5-isothiocyanoatonorbornane, 1-isothiocyanato-5-methylsulfonylpentane, and cis- or trans-3-(methylsulfonyl)-cyclohexylmethyl-isothiocyanate, and mixtures thereof.
A pharmaceutical composition comprising a complex of cyclodextrin and sulforaphane, or an analog of sulforaphane selected from the group consisting of 6-isothiocyanato-2-hexanone, exo-2-acetyl-6-isothiocyanatonorbornane, exo-2-isothiocyanoat-6-methylsulfonylnorbornane, 6-isothiocyanato-2-hexanol, 1-isothiocyanato-4-dimethylphosphonylbutane, exo-2-(1′-hydroxyethyl)-5-isothiocyanatonorborane, exo-2-acetyl-5-isothiocyanoatonorbornane, 1-isothiocyanato-5-methylsulfonylpentane, and cis- or trans-3-(methylsulfonyl)-cyclohexylmethyl-isothiocyanate, and mixtures thereof, and an excipient.
A nutraceutical composition comprising a complex of cyclodextrin and sulforaphane, or an analog of sulforaphane one or more of 6 isothiocyanato-2-hexanone, exo-2-acetyl-6-isothiocyanatonorbornane, exo-2-isothiocyanato-6-methylsulfonylnorbornane, 6-isothiocyanato-2-hexanol, 1-isothiocyanato-4-dimethylphosphonylbutane, exo-2-(1′-hydroxyethyl)-5-isothiocyanatonorborane, exo-2-acetyl-5-isothiocyanoatonorbornane, 1-isothiocyanato-5-methylsulfonylpentane, and cis- or trans-3-(methylsulfonyl)-cyclohexylmethyl-isothiocyanate, and mixtures thereof, and an excipient.
Dependencies are inferred from the claim text.