Treatment of metastatic colon cancer with b-subunit of shiga toxin
AssigneeThe Johns Hopkins University
InventorsOlga N. Kovbasnjuk, Mark Donowitz
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Abstract
The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further provides methods of identifying compounds usefully for the treatment of invasive or metastatic cancer, particularly metastatic colon cancer.
Claims10
A method of reducing, or inhibiting invasiveness and metastasis of tumor cells in a subject, wherein the tumor cells produce Gb3, comprising administering to the subject a therapeutically effective amount of a Stx1B-subunit of Shiga toxin.
A method of reducing, or inhibiting invasiveness and metastasis of colon tumor cells in a subject, wherein the tumor cells produce Gb3, comprising administering to the subject a therapeutically effective amount of a Stx1B-subunit of Shiga toxin.
Dependencies are inferred from the claim text.