Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures

A method comprising:

• providing first data associated with a first signal received from at least one region of at least one sample based on a first modality, and second data associated with a second signal received from the at least one sample based on a second modality which is different from the first modality, wherein the first and second data are provided substantially simultaneously;
• receiving third data associated with a reference;
• and
• using a configured computing arrangement, generating further data based on the first, second and third data.

An apparatus comprising:

• first arrangement configured to provide first data associated with a first signal received from at least one region of at least one sample based on a first modality, and second data associated with a second signal received from the at least one sample based on a second modality which is different from the first modality, wherein the first arrangement is further configured to receive third data associated with a reference, wherein the first arrangement is provided in at least one of a probe or a single enclosure;
• second arrangement configured to generate further data based on the first, second and third data;
• and
• a positioning third arrangement configured to position the at least one of the probe or the single enclosure at a particular location relative to the sample based on at least one of the first data or the second data.