# US 7,871,765 B2 · Composition having antitumor effect

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- Number: US 7,871,765 B2
- Document ID: US7871765B2
- Status: Granted
- Kind: B2
- Application number: 10/594,443
- Filed: 2005-03-31
- Published: 2008-09-18
- Granted: 2011-01-18
- Earliest claimed: 2004-03-31
- Assignees: Genomidea Inc.; AnGesMG, Inc.
- Inventors: Hitoshi Kotani; Yasufumi Kaneda; Hirokazu Kawano; Masayuki Fukumura; Masayuki Kurooka
- Web page: https://patentgrep.com/patent/US7871765B2

## CPC

- A61K 9/5184: {Virus capsids or envelopes enclosing drugs (liposomes with additional exogenous lipids A61K9/127)}
- A61K 31/24: having an amino or nitro group
- A61K 31/282: Platinum compounds
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 31/7064: containing condensed or non-condensed pyrimidines
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61K 2039/55561: {CpG containing adjuvants; Oligonucleotide containing adjuvants}
- A61K 2039/55572: {Lipopolysaccharides; Lipid A; Monophosphoryl lipid A}
- A61K 2039/585: {wherein the target is cancer}
- A61K 2039/6006: {Cells}
- C12N 2760/18842: virus or viral particle as vehicle, e.g. encapsulating small organic molecule
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.

## Claims

### Claim 1

A method for inhibiting tumor cell growth in an animal, comprising administering to said animal an effective amount of a composition consisting of a hemagglutinating virus of Japan envelope (HVJ-E) and a pharmaceutically acceptable carrier, wherein the composition is administered intratumorally.

### Claim 2 (depends on 1)

The method of claim 1 wherein IL-12 and IL-6 in dendritic cells are induced or regulatory T cells are inhibited.