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US 7,871,623 B2Granted
Compositions and methods for imaging pain and stress in vivo
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSandip Biswal, Francis G. Blankenberg
Life of this patent
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Abstract
Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.
Claims34
A method of imaging pain in a subject in vivo comprising:
- administering to the subject an imaging composition comprising a labeled annexin including annexin coupled to a biocompatible radionuclide;
- and
- measuring radiation emission from the radionuclide in the subject to construct an image of radiation emission, wherein the image is a representation of pain in the subject.
A method of imaging pain in a subject in vivo comprising:
- administering to the subject an imaging composition comprising a labeled annexin including annexin coupled to a contrast agent;
- and
- obtaining a magnetic resonance image, wherein said image is a representation of pain in said subject.
Dependencies are inferred from the claim text.