Immunogenic peptides derived from sclerostin
AssigneeUCB Manufacturing, Inc.
InventorsDavid G. Winkler, Jiye Shi, John Latham
Life of this patent
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Abstract
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
Claims20
An immunogen comprising a peptide of no more than 75 consecutive amino acids of a SOST polypeptide of SEQ ID NO:
- 1, 20, 58, 60, 62 or 68, said peptide comprising at least 4 consecutive amino acids of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 29, 30, 31, 32, 53, and 54, wherein the peptide is capable of eliciting an antibody that binds specifically to the SOST polypeptide.
An immunogen comprising a peptide, wherein the peptide is a fragment of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 29, 30, 31, 32, 53, and 54, wherein the peptide comprises at least 4 consecutive amino acids of the amino acid sequence, and wherein the peptide is capable of eliciting an antibody that binds specifically to the SOST polypeptide.
An immunogen comprising a peptide, wherein the peptide is a fragment of SEQ ID NO:
- 53 comprising at least 4 consecutive amino acids of SEQ ID NO:
- 53, and wherein the peptide is capable of eliciting an antibody that binds specifically to the SOST polypeptide.
Dependencies are inferred from the claim text.