Systems and methods for performing peritoneal dialysis

A system for providing dialysis comprising:

• a patient fluid loop including a first pump, a first patient lumen for providing fluid to the patient, and a second patient lumen for removing fluid from the patient;
• a multiple lumen connector for connecting with the first and second patient lumens of the patient fluid loop, the connector configured to be sealed by a removable connector end cap such that the pump can prime the patient, wherein the first patient lumen extends further into the multiple lumen connector than the second patient lumen fluid loop prior to being connected to the patient;
• a second fluid loop including a second pump, a medical fluid regenerator, and a gas separator that separates gases from the second fluid loop;
• a membrane device in fluid contact with and separating the patient fluid loop and the second fluid loop, the membrane device allowing at least one selected component of the fluid in the patient fluid loop to transfer to the second fluid loop;
• the second loop being closed except for the transfer of the selected component via the membrane device;
• and
• a controller that operates the first and second pumps to recirculate fluid in the patient loop and the second loop.