Process for the purification of ropinirole hydrochloride
AssigneeAlembic Limited
InventorsPandurang Balwant Deshpande, Parven Kumar Luthra, Hitarth Harshendu Acharya
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Abstract
The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Claims5
A process for purification of Ropinirole hydrochloride of formula (Ia)
- comprising:
- (i) treating Ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent;
- (ii) triturating Ropinirole hydrochloride obtained in step (i) with ethanol;
- (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base;
- and
- (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.
Dependencies are inferred from the claim text.