US 7,863,414 B2 · Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain

Abstract

The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.

Claims9

Dependent claims

A method of treating cardiac hypertrophy, heart failure, dilated cardiomyopathy, or arrhythmias comprising:

(a) identifying a subject suffering from or at risk of developing cardiac hypertrophy, heart failure, dilated cardiomyopathy, or arrhythmias;
and
(b) administering to said patient an Histone Deacetylase (HDAC) 4 peptide of 5 to 25 consecutive residues of HDAC4 and comprising the docking site to Calcium/Calmodulin Kinase II (CaMKII), or a CaMKII peptide of 5 to 25 consecutive residues of CaMKII and comprising the docking site to HDAC4, that inhibits the interaction between HDAC4 and CaMKII.

Dependencies are inferred from the claim text.

Facts

Application

11/560,950Filed 17 Nov 2006 · us provisional application

Priority

18 Nov 2005

Published

US 2007/0142285 A121 Jun 2007

Granted

4 Jan 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12Q 1/485
Involving transferase: involving kinase
A61K 38/45
Enzymes; Proenzymes; Derivatives thereof: transferases
A61K 38/50
Hydrolases: acting on carbon-nitrogen bonds, other than peptide bonds , e.g. asparaginase
A61P 9/00
Drugs for disorders of the cardiovascular system

Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain

Life of this patent

Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain

Life of this patent

Abstract

Claims9