Prion protein ligands and methods of use
AssigneesPathogen Removal and Diagnostics Technologies Inc., North Carolina State University
InventorsDavid J. Hammond, Julia T. Lathrop, Larisa Cervenakova, Ruben G. Carbonell
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Abstract
Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.
Claims27
An isolated prion-binding peptide ligand, wherein the ligand is capable of binding to a peptide having the amino acid sequence RYPGQ (SEQ ID NO:1);
- and wherein the ligand is a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS:5-13.
An isolated prion-binding ligand, wherein the ligand is capable of binding to a native form of prion protein (PrPc) and is a peptide consisting of an amino acid sequence SEQ ID NO:
- 116.
Dependencies are inferred from the claim text.