Continuous administration of dopa decarboxylase inhibitors and compositions for same
AssigneeNeuroDerm, Ltd.
InventorsOron Yacoby-Zeevi, Mara Nemas
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Abstract
Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
Claims11
A pharmaceutically acceptable liquid composition comprising about 2% to about 6% by weight carbidopa, and arginine, wherein the pH of the liquid composition is about 8 to about 9 at 25° C., wherein the carbidopa and the arginine have a molar ratio of about 1:0.5 to about 1:2.5, and wherein the liquid composition is stable at 25° C. for 48 hours or more.
Dependencies are inferred from the claim text.