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US 7,858,583 B2Granted
Process for purifying glycopeptide phosphonate derivatives
AssigneeTheravance, Inc.
InventorsDonald E. Schmidt, Jr., Jeanmarie Donovan Sganga
Life of this patent
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Abstract
Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, eluting the resin with an aqueous solution, and isolating the purified glycopeptide derivative.
Claims7
A composition comprising:
- (a) a compound of the formula:
- or a salt thereof;
- (b) a polystyrene divinyl benzene resin;
- and
- (c) an acidified aqueous solution comprising a polar organic solvent selected from methanol, ethanol, isopropyl alcohol and acetonitrile;
- wherein the acidified aqueous solution contains acetic acid or hydrochloric acid.
3 more elements
Dependencies are inferred from the claim text.