Methods and apparatus for conducting multiple measurements on a sample

A method for assaying for an analyte of interest comprising

• (a) introducing a sample comprising said analyte into a multi-well plate having a plurality of wells and at least two assay domains located within a single well of said plurality wells, said at least two assay domains including (i) a first domain comprising a first component that binds said analyte, and (ii) a second domain comprising a second component that competes with said analyte;
• (b) conducting in said single well a sandwich assay and a competitive assay, wherein the amount of said analyte is separately quantified in said sandwich assay and said competitive assay;
• and
• (c) comparing the amounts of said analyte identified in step (b) in said sandwich and said competitive assays to determine if a dynamic range of said sandwich assay has been exceeded.