Methods and apparatus for multi-vessel renal neuromodulation
AssigneeArdian, Inc.
InventorDenise Demarais
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Abstract
Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.
Claims31
A method for multi-vessel renal neuromodulation of a patient, the method comprising:
- placing a first electrode around or near a first renal artery of the patient and in proximity to a first neural fiber that innervates a first kidney of the patient;
- placing a second electrode around or near a second renal artery of the patient and in proximity to a second neural fiber that innervates a second kidney of the patient;
- and
- passing electrical current through the first electrode and the second electrode to modulate the functions of the first and second neural fibers.
A method for a renal neuromodulation of a patient, the method comprising:
- placing a first electrode within a first vessel of a patient at least substantially proximate to a neural fiber that contributes to a function of a kidney of the patient;
- placing a second electrode within a second vessel of the patient, wherein the second vessel is a different vessel than the first vessel;
- and
- delivering an electric field between the first electrode and the second electrode and modulating the function of the neural fiber.
Dependencies are inferred from the claim text.