Back to results
US 7,850,958 B2Granted
Recombinant double stranded RNA nucleocapsid and use of the same
AssigneeUniversity of Maryland Biotechnology Institute
InventorDavid Hone
Life of this patent
Estimating the term…
Abstract
A recombinant double stranded RNA (dsRNA) nucleocapsid useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs, replicates in bacterial hosts and includes a P8 protein shell and three dsRNA segments where one of the segments includes a cap independent translation enhancer (CITE) operationally linked to a passenger gene.
Claims1
A recombinant double stranded RNA (dsRNA) nucleocapsid with a P8 protein shell and three dsRNA segments, wherein
- i) at least one of said three dsRNA segments comprises a cap independent translation enhancer (CITE) operationally linked to a passenger gene;
- and
- ii) said dsRNA nucleocapsid replicates in bacterial host cells.
Dependencies are inferred from the claim text.