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US 7,850,949 B2Granted
Purification of synthetic oligomers
AssigneeMichigan Technological University
InventorShiyue Fang
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Abstract
This invention provides a novel method for purifying synthetic oligomers comprising capping, polymerizing and separating any failure sequences produced during oligomer synthesis. Either the failure sequence or the full-length oligomer may be polymerized. Optionally, small molecule impurities may also be incorporated into the polymerized material. The invention provides novel capping agents having a polymerizable functional group. The invention also provides kits comprising at least one composition of the present invention.
Claims1
A method of purifying an oligomer comprising:
- capping any failure sequences produced during synthesis with a capping agent haying a polymerizable functional group;
- polymerizing the capped failure sequences;
- and
- separating the polymerized material from the full-length oligomer;
- wherein the capping agent is a compound of formula (IV):
- wherein R1 is a halogen or a secondary amine;
- R4 is
- t is an integer from 1 to 3.
5 more elements
Dependencies are inferred from the claim text.