Granulocyte adsorbent
AssigneeKaneka Corporation
InventorsAkira Kobayashi, Shinya Yoshida, Hideo Niwa
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Abstract
This invention relates to a granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with at least one substituent R, a method for producing such adsorbent, a device for adsorbing granulocytes and a system for removing granulocytes using such adsorbent, and body fluid or a cell suspension from which granulocytes have been removed using such adsorbent.
Claims8
A granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with acetyl, wherein the polymer compound is at least one selected from
- cellulose acetate in which the percentage of hydroxyl groups substituted with acetyl groups is 44% to 51% among all hydroxyl groups, and
- polyvinyl acetate in which the percentage of hydroxyl groups substituted with acetyl groups is 35% to 49% among all hydroxyl groups.
A method for producing a granulocyte adsorbent comprising steps of:
- (a) obtaining polyvinyl acetate;
- and
- (b) cleaving part of acetyl groups of said polyvinyl acetate by treating said polyvinyl acetate under alkaline conditions,
- wherein said polyvinyl acetate has an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with acetyl, wherein the percentage of hydroxyl groups substituted with acetyl groups in said polyvinyl acetate is 35% to 49% among all hydroxyl groups.
Dependencies are inferred from the claim text.