# US 7,850,634 B2 · Method for collecting a desired blood component and performing a photopheresis treatment

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- Number: US 7,850,634 B2
- Document ID: US7850634B2
- Status: Granted
- Kind: B2
- Application number: 11/613,021
- Filed: 2006-12-19
- Published: 2007-05-03
- Granted: 2010-12-14
- Earliest claimed: 2002-03-04
- Assignees: Therakos, Inc.
- Inventors: Dennis Briggs
- Web page: https://patentgrep.com/patent/US7850634B2

## CPC

- A61M 1/3696: {with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation}
- A61K 41/0066: {Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins}
- A61M 1/0227: {and means for securing the filter against damage, e.g. during centrifugation}
- A61M 1/3603: {in the same direction}
- A61M 1/361: {before treatment}
- A61M 1/36224: {with sensing means or components thereof}
- A61M 1/36225: {with blood pumping means or components thereof}
- A61M 1/362264: {the filter being a blood filter}
- A61M 1/362266: {Means for adding solutions or substances to the blood}
- A61M 1/3681: {by irradiation}
- A61M 1/3683: {using photoactive agents}
- A61M 1/3686: {by removing photoactive agents after irradiation}
- A61M 1/3693: {using separation based on different densities of components, e.g. centrifuging}
- A61M 1/72: {Cassettes forming partially or totally the fluid circuit}
- A61M 1/77: {Suction-irrigation systems (aspiration tips supplying fluids A61M1/85; specific for negative pressure wound therapy A61M1/92; combined with tracheal tubes A61M16/0463)}
- A61M 3/0201: {Cassettes therefor}
- B04B 5/0442: {with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation}
- F04B 43/1253: {by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing}
- A61M 2202/0092: starting product created by centrifuging
- A61M 2202/0427: Platelets; Thrombocytes
- A61M 2205/051: with radiation therapy
- A61M 2205/053: ultraviolet
- A61M 2205/12: with interchangeable cassettes forming partially or totally the fluid circuit
- A61M 2205/125: with incorporated filters
- A61M 2205/35: Communication
- A61M 2205/3569: sublocal, e.g. between console and disposable
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/60: with identification means
- A61M 2205/75: with filters
- B04B 2005/0464: {with hollow or massive core in centrifuge bowl}
- B04B 2005/0492: {with fluid conveying umbilicus between stationary and rotary centrifuge parts}
- F28F 2260/02: having microchannels
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B04B: CENTRIFUGES (high-speed drum mills B02C19/11; domestic spin driers D06F; analysing, measuring or monitoring physical or chemical properties of samples during centrifuging, see the relevant subclasses for these procedures, e.g. G01N)
- F04B: POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS (machines for liquids, or pumps, of rotary-piston or oscillating-piston type F04C; non-positive-displacement pumps F04D; pumping of fluid by direct contact of another fluid or by using inertia of fluid to be pumped F04F)
- F28F: DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION (water and air traps, air venting F16)

## Abstract

An improved method for separating whole blood into components and collecting a desired blood component. The method allows a desired blood component to be subjected to centrifugal forces within a separator for prolonged periods of time, yielding a cleaner cut and higher yield of the desired blood component. Whole blood is drawn from a source and pumped into a separator, the undesired blood components are removed from the separator at rates so as to build up the desired blood component in the separator. The desired blood component is only removed after a predetermined amount of the desired blood component has built up in the separator. It is preferred that the desired blood component be buffy coat and that the method be used to perform photopheresis treatments. In another aspect, the invention is a method of performing a full photopheresis treatment to treat diseases in a reduced time, preferably less than about 70 minutes, and more preferably less than about 45 minutes.

## Claims

### Claim 1

An apparatus comprising a disposable kit, the kit comprising a cassette; a saline bag inlet tube; a treatment bag; a plasma collection bag having an inlet tube for flowing plasma from the cassette and an outlet tube for flowing plasma to the cassette; an anticoagulant inlet tube for flowing anticoagulant to the cassette; an irradiation chamber having an inlet tube for flowing buffy coat from the cassette and an outlet tube for flowing irradiated buffy coat to the cassette; a separation bowl having one tube for flowing blood to the separation chamber and at least two tubes for flowing separate blood fragments from the separation chamber; means to withdraw blood from a patient comprising a tube for flowing blood to the cassette; and means to return blood fractions to the patient comprising a tube from the cassette, and two or more needle adapters wherein one of said needle adapters is for withdrawing said biological fluid from a patient and at least one other is for returning one or more components to the patient.

### Claim 2 (depends on 1)

The kit of claim 1 further comprising a hematocrit sensor and a data card.

### Claim 3 (depends on 1)

The kit of claim 1 further comprising a photoactive compound.

### Claim 4 (depends on 1)

The kit of claim 1 further comprising a therapeutic compound.

### Claim 5 (depends on 1)

The kit of claim 1 further comprising two needles.

### Claim 6 (depends on 1)

The kit of claim 1 further comprising instructions for arranging said kit for either single or double needle treatment and for switching the configuration of such arrangements from single to double needle or from double to single needle.