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US 7,847,093 B2Granted
Processes for the preparations of cefepime
AssigneeSandoz Ltd.
InventorsJohannes Ludescher, Hubert Sturm, Siegfried Wolf
Life of this patent
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Abstract
This invention provides processes for preparing cefepime, including crystalline intermediates of Formula V.
Claims7
A process for producing a compound of formula I
- wherein a compound of formula IIA, or a hydrate of a compound of formula IIA,
- wherein n is 1 or 2 and X signifies chloride, bromide or iodide, is reacted with a reactive derivative of formula III
- wherein Y signifies halogen, to form a compound of formula V
- wherein m is 1 and wherein optionally the compound of formula V is isolated, wherein the compound of formula V is cyclised with thiourea in an aqueous or organic-aqueous medium, wherein optionally salt that is present is then removed, and wherein the compound of formula I is subsequently isolated from aqueous acetonic solution after addition of hydrochloric acid.
1 more element
A process for producing a compound of formula I
- wherein a compound of formula IIB
- wherein
- R1 is a trialkylsilyl group,
- R is hydrogen or a trialkylsilyl group, and
- X signifies chloride, bromide or iodide is reacted with a reactive derivative of formula III
- wherein Y signifies halogen, to form a compound of formula IV
- wherein T is trialkylsilyl, the silyl protecting group is removed to form a compound of the formula V, wherein m is 1,
- wherein optionally the compound of formula V is isolated, and wherein the compound of formula V is cyclized with thiourea in an aqueous or organic-aqueous medium and wherein optionally salt that is present is then removed, and wherein the compound of formula I is subsequently isolated from aqueous acetonic solution after addition of hydrochloric acid.
5 more elements
A compound of formula V
- wherein Y and X are Cl and wherein m=1.
Dependencies are inferred from the claim text.