Albumin fusion proteins
AssigneeHuman Genome Sciences, Inc.
InventorsCraig A. Rosen, William A. Haseltine, Steven M. Ruben
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Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
Claims30
A nucleic acid molecule comprising a first polynucleotide encoding two or more tandem GLP-1 polypeptides, wherein said GLP-1 polypeptides are selected from wild-type GLP-1, GLP-1 fragments, and GLP-1 variants, and a second polynucleotide encoding human albumin or a human albumin fragment or variant thereof.
A nucleic acid molecule comprising the cDNA contained in ATCC Deposit No. PTA-4671.
Dependencies are inferred from the claim text.