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US 7,846,393 B2Granted
Membrane filter for capturing circulating tumor cells
AssigneesCalifornia Institute of Technology, University of Southern California
InventorsYu-Chong Tai, Siyang Zheng, Henry Lin, Ram Datar, Richard Cote
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Abstract
The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
Claims21
A membrane filter device, said device comprising:
- a membrane filter consisting of a parylene substrate, a portion of said membrane filter having an array of holes with a predetermined geometric design, wherein the array of holes is between 1,000 and 40,000 per square millimeter;
- a pressure generating device coupled to the filter for applying pressure to a sample to be filtered;
- and
- a housing surrounding said membrane filter wherein said portion is suspended free of the housing.
1 more element
A membrane filter device, said membrane filter device comprising:
- a first membrane filter consisting of a parylene substrate, a portion of said membrane filter having an array of holes with a first predetermined geometric design, wherein the array of holes is between 1,000 and 40,000 per square millimeter and;
- a pressure generating device coupled to the filter for applying pressure to a sample to be filtered;
- and a housing surrounding said membrane filter wherein said portion is suspended free of the housing.
Dependencies are inferred from the claim text.