Method and apparatus for transmission mode ion/ion dissociation
AssigneePurdue Research Foundation
InventorsScott A. McLuckey, Xiaorong Liang, Yu Xia
Life of this patent
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Abstract
A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmitted through the stored first species. The resultant reaction products may be analyzed by a mass analyzed taking account of the remaining charge values. In an aspect, a linear ion trap may be used as the reaction volume, and the ionized species injected along the axis of the trap in a substantially collinear manner. The mass analysis may be performed by mass selective axial ejection or by a mass spectrometer.
Claims24
A method of operating an ion trap, the method comprising:
- creating an ion trapping volume within a chamber of the ion trap;
- injecting a first population of ions into the ion trapping volume so that the first population is stored in the ion trapping volume;
- and
- transmitting a second population of charged ions through the ion trapping volume.
An apparatus for analyzing molecules, the apparatus comprising:
- a linear ion trap (LIT), configured to:
- accept and store a first population of ions;
- transmit a second population of ions through the first population of ions;
- and,
- a mass analyzer,
- wherein one of the first population or the second population is analyzed by the mass analyzer.
Dependencies are inferred from the claim text.