Method for producing optically active cycloalkylidenebisoxazoline compound and intermediate thereof
AssigneeSumitomo Chemical Company, Limited
InventorMakoto Itagaki
Life of this patent
Estimating the term…
Abstract
It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group and * represents an asymmetric center, a method for producing it and a method for producing an optically active cycloalkylidenebisoxazoline compound represented by the formula (4): wherein R1, R2 and * are as defined above, using thereof.
Claims10
A method for producing the optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3):
- wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or
- two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded,
- R2 represents a C1-6 alkyl group, an optionally substituted phenyl group or an optionally substituted aralkyl group, n represents an integer of 0 to 3, and * represents an asymmetric center,
- which comprises reacting an optically active aminoalcohol compound represented by the formula (1):
- wherein R1, R2 and * are as defined above, with a cycloalkylidenemalonic acid diester compound represented by the formula (2):
- wherein R3 represents a C1-3 alkyl group and n represents an integer of 0 to 3, in the presence of a lithium compound.
Dependencies are inferred from the claim text.