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US 7,842,825 B2Granted
Biaryloxymethylarenecarboxylic acids as glycogen synthase activator
AssigneeHoffmann-La Roche Inc.
InventorsChang An Chu, Paul Gillespie, Jefferson Wright Tilley
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Abstract
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
Claims9
A pharmaceutical composition comprising a compound of formula(1a)
- wherein
- Ar is a phenyl ring;
- R1, R2 and R3 are independently selected from the group consisting of lower alkyl, lower alkoxy, trifluoromethyl, halogen, hydroxy, amino, alkylamino, dialkylamino, cyano and nitro;
- R4 is hydroxy or an amino acid attached through a nitrogen atom of the amino acid;
- n is 0, 1, 2, 3, 4 or 5;
- m is 0, 1, 2, 3 or 4;
- p is 0, 1 or 2, and
- s is 0, 1 or 2
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient
- provided when Ar is phenyl, the compound is not either 3-(biphenyl-4-yloxymethyl)-benzoic acid or 2-(biphenyl-3-yloxymethyl)-benzoic acid.
7 more elements
Dependencies are inferred from the claim text.