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US 7,842,819 B2Granted
Derivatives for modulation of ion channels
AssigneeVertex Pharmaceuticals Incorporated
InventorsEsther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Zimmermann, Corey Don Gutierrez
Life of this patent
Estimating the term…
Abstract
Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
Claims28
A compound having the structure of formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Ring B is optionally substituted with 1-2 of halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Ra is independently H, aliphatic, phenyl or benzyl, wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Rb is independently H, aliphatic, phenyl or benzyl, wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic, or
- Ra and Rb together with the nitrogen atom to which they are bound form a heterocyclic ring optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Q is a branched or unbranched C1-C4-alkyl optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each L is absent, —O—, —NRc-, or —S—;
- Each Rc is H, or aliphatic optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Rw is phenyl, indole, or quinoline, wherein the phenyl, indole, or quinoline is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each n is 1, 2, or 3;
- and
- Each m is 1, 2, or 3, provided that the sum of n and m is 3, 4, 5, or 6.
10 more elements
A compound having the structure of formula II:
- or a pharmaceutically acceptable salt thereof, wherein
- Ring B is optionally substituted with 1-2 of halo, cyano, nitro, haloalkyl, alkoxy, sulfonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Ra is independently H, aliphatic, phenyl or benzyl, wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Rb is independently H, aliphatic, phenyl or benzyl, wherein the aliphatic, phenyl, or benzyl is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic, or
- Ra and Rb together with the nitrogen atom to which they are bound form a heterocyclic optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Rq is H or aliphatic optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each LII is absent, —CH2—, —O—, —NRc-, or —S—;
- Each Rc is H, or aliphatic optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- Each Rw is phenyl, indole, or quinoline, wherein the phenyl, indole, or quinoline is optionally substituted with halo, cyano, nitro, haloalkyl, alkoxy, sufonyl, sulfinyl, sulfanyl, amino, carboxy, or aliphatic;
- and
- Each p is 1 or 2.
8 more elements
A compound selected from
- 1
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- and
- 27
25 more elements
Dependencies are inferred from the claim text.