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US 7,842,817 B2Granted
2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
AssigneeNeuroSearch A/S
InventorsUlrik Svane Sørensen, Lene Teuber, Dan Peters, Dorte Strøbæk, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen
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Abstract
This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims6
A 2-amino benzimidazole derivative of Formula Ib:
- or any of its isomers or any mixture of its isomers,
- or a pharmaceutically acceptable salt thereof, wherein
- m is 1;
- n is 1;
- R′ is hydrogen;
- R1 represents 4-fluorophenyl, 3,4-difluorophenyl, or 3,5-difluorophenyl, and R2 represents 4-fluorophenyl, 3,4-difluorophenyl, or 3,5-difluorophenyl;
- and
- R4, R5, R6 and R7 are hydrogen.
5 more elements
Dependencies are inferred from the claim text.