Human CDR-grafted antibody and antibody fragment thereof
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsKenya Shitara, Kazuyasu Nakamura, Emi Hosaka, Akiko Shimizu, Masamichi Koike
Life of this patent
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Abstract
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.
Claims6
A DNA encoding a human CDR-grafted antibody, or antigen-binding fragment thereof, which reacts with an extracellular region of human CC chemokine receptor 4 (CCR4), but does not specifically react with a human platelet, wherein said antibody or antigen-binding fragment thereof comprises an antibody heavy chain (H chain) variable region (V region) comprising the amino acid sequence of SEQ ID NO:
- 4, 9, 10, 11, 38, 39, 40 or 41.
A DNA encoding a human CDR-grafted antibody, or antigen-binding fragment thereof, which reacts with an extracellular region of human CC chemokine receptor 4 (CCR4), but does not specifically react with a human platelet, wherein said antibody or antigen-binding fragment thereof comprises an antibody light chain (L chain) variable region (V region) comprising the amino acid sequence of SEQ ID NO:
- 8, 12, 13 or 14.
A DNA which encodes the antibody produced by a transformant KM8759 (FERM BP-8129) or KM8760 (FERM BP-8130), or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.