PUFA polyketide synthase systems and uses thereof
AssigneeMartek Biosciences Corporation
InventorsJames G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
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Abstract
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
Claims22
An isolated nucleic acid molecule comprising a nucleic acid sequence encoding an amino acid sequence that is at least 95% identical to SEQ ID NO:26 or that is an enzymatically active fragment of SEQ ID NO:26, wherein said amino acid sequence has enoyl reductase activity.
Dependencies are inferred from the claim text.