Antibodies against human parathyroid hormone related protein
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKoh Sato, Yuji Wakahara, Naohiro Yabuta
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Abstract
Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
Claims11
An agent for improving at least one of the symptoms of hypercalcemia associated with malignant tumor, said agent comprising as an active ingredient an antibody that specifically binds to and at least partially neutralizes human parathyroid hormone related protein (1-34) [PTHrP (1-34)] comprising the amino acid sequence of SEQ ID NO:
- 75, wherein said antibody comprises a heavy (H) chain variable (V) region comprising complementarity determining regions (CDRs) comprising the amino acid sequences of SEQ ID NOs:
- 62-64 and a light (L) chain V region comprising CDRs comprising the amino acid sequences of SEQ ID NOs:
- 59-61.
Dependencies are inferred from the claim text.