Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
AssigneesThe Regents of the University of California, The United States of America/NIH
InventorsCharles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Gregory A Nelson
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Abstract
The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
Claims28
An isolated receptor, wherein the receptor comprises a T1R3 polypeptide and a heterologous polypeptide, wherein the T1R3 polypeptide has at least 94% amino acid sequence identity to SEQ ID NO:25 and the heterologous polypeptide is a T1R1 polypeptide that has at least 90% amino acid sequence identity to SEQ ID NO:1.
Dependencies are inferred from the claim text.