Silk fibroin materials and use thereof
AssigneesTrustees of Tufts College, Massachusetts Institute of Technology
InventorsDavid L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
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Abstract
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
Claims10
A porous silk fibroin material comprising a three-dimensional silk fibroin body having interconnected pores, wherein the mean pore size of the silk fibroin body is in the range of 225 μm to 425 μm and wherein the material has a compressive modulus of at least 100 kPa.
Dependencies are inferred from the claim text.