Anti tubercular drug: compositions and methods
AssigneesThe United States of America as represented by the Department of Health and Human Services, Sequella, Inc.
InventorsMarina Nikolaevna Protopopova, Richard Edward Lee, Richard Allan Slayden, Clifton E. Barry, III, Elena Bogatcheva, Leo Einck
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Abstract
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
Claims24
A method of treating disease caused by a mycobacterial agent, comprising administering to a human or a non-human animal an effective amount of a substituted ethylene diamine compound of the formula:
- wherein R4 is selected from H, alkyl, aryl, alkenyl, alkynyl, aralkyl, aralkynyl, cycloalkyl, cycloalkenyl;
- and wherein R1, R2 and R3 are independently selected from H, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkenyl, halide, alkoxy, aryloxy, alkylthio, arylthio, silyl, siloxy, amino, heteroaryl or aryl;
- or
- wherein when R1 is selected from H, alkenyl, alkynyl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkenyl, halide, alkoxy, aryloxy, alkylthio, arylthio, silyl, siloxy, amino, and NR2R3 is a cyclic secondary amine;
- or a pharmaceutically acceptable salt thereof.
A method of treating disease caused by a mycobacterial agent, comprising administering to a human or a non-human animal an effective amount of a substituted ethylene diamine compound of the formula
- or a pharmaceutically acceptable salt thereof.
A method for treating a disease caused by a mycobacterial agent, comprising administering to a human or a non-human animal a pharmaceutically effective amount of a compound of formula
Dependencies are inferred from the claim text.