Carnitine derivative, salt thereof, external skin preparation and cosmetic material
AssigneeShowa Denko K.K.
InventorsHirobumi Aoki, Harumi Kamachi, Yohei Kurata
Life of this patent
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Abstract
To provide novel carnitine derivatives and salts thereof that are resistant to hydrolysis in the presence of aqueous media, and also provide external skin preparations and cosmetics that are excellent in storage stability, product life, skin affinity and percutaneous absorption properties. In particular, to provide novel α-branched acyl carnitine derivatives and salts thereof, external skin preparations and cosmetics comprising specific α-branched acyl carnitine derivatives and/or salts thereof.
Claims21
An external skin preparation comprising a carnitine derivative represented by Formula (1) and/or a salt of carnitine derivative represented by Formula (2):
- wherein one of R1 and R2 is a saturated aliphatic hydrocarbon group of 2 to 16 carbon atoms that may have a branch, and the other is a saturated aliphatic hydrocarbon group of 8 to 16 carbon atoms that may have a branch;
- wherein R1 and R2 are as defined in Formula (1), X− is an inorganic or organic anion that maintains electrical neutrality with a cation part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anion part of the carnitine derivative.
A carnitine derivative represented by Formula (3):
- wherein one of R3 and R4 is a saturated aliphatic hydrocarbon group of 1 to 16 carbon atoms that may have a branch, and the other is a saturated aliphatic hydrocarbon group of 8 to 16 carbon atoms that may have a branch.
A salt of carnitine derivative represented by Formula (4):
- wherein one of R3 and R4 is a saturated aliphatic hydrocarbon group of 1 to 16 carbon atoms that may have a branch, the other is a saturated aliphatic hydrocarbon group of 8 to 16 carbon atoms that may have a branch, X− is an inorganic or organic anion that maintains electrical neutrality with a cation part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anion part of the carnitine derivative.
A carnitine derivative represented by Formula (7):
A salt of carnitine derivative represented by Formula (8):
- wherein X− is an inorganic or organic anion that maintains electrical neutrality with a cation part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anion part of the carnitine derivative.
A carnitine derivative represented by Formula (9):
A salt of carnitine derivative represented by Formula (10):
- wherein X− is an inorganic or organic anion that maintains electrical neutrality with a cation part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anion part of the carnitine derivative.
A carnitine derivative represented by Formula (11):
A salt of carnitine derivative represented by Formula (12):
- wherein X− is an inorganic or organic anion that maintains electrical neutrality with a cation part of the carnitine derivative, and Y+ is an inorganic or organic cation that maintains electrical neutrality with an anion part of the carnitine derivative.
Dependencies are inferred from the claim text.