Composition for treating cancer cells and synthetic method for the same
AssigneeKaohsiung Medical University
InventorsAn-Shen Lin, Yang-Chang Wu, Kuo-Hsiung Lee, Fang-Rong Chang
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Abstract
A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R1-R12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.
Claims17
A pharmaceutical composition having a cytotoxic effect to a cancer cell comprising:
- a flavonoid compound having at least one of the following formulas:
- wherein:
- B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R1-R12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar;
- when R2 of formula 1 is a hydroxyl group, R4 of formula 1 is one selected from a group consisting of hydrogen group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar;
- and
- when R4 of formula 1 is a hydroxyl group, R2 of formula 1 is one selected from a group consisting of hydrogen group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar.
A synthesis method for synthesizing a specific flavonoid compound comprising steps of:
- providing a flavonoid compound comprising a 4′-hydroxy group;
- and
- mixing the flavonoid compound with a first catalyzer and an iodobenzene compound to obtain the specific flavonoid compound.
Dependencies are inferred from the claim text.