Anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities
AssigneeElsohly Laboratories, Incorporated
InventorsMahmoud A. Elsohly, Waseem Gul
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Abstract
This invention comprises compositions containing dihydroartemisinin- and dihydroartemisitene-dimers with activity as anticancer or anticancer metastasis agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer or prevention of cancer metastasis, and protozoal infections, including malaria, or leishmaniasis. The compounds of this invention represent a potential new class of anti-tumor or anti-metastasis agents, one that has shown promising activity against solid tumors.
Claims49
A method of treating cancer or inhibiting cancer metastasis comprising administering to a subject suffering from cancer an effective amount of at least one compound of the formula:
- Where R is:
- where R1 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- where R2 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- or a compound of the formula
- where R5 is selected from one of the substituents described above for R.
A method of treating a protozoal infection comprising administering to a subject suffering from an infection an effective amount of at least one compound of the formula:
- where R is
- where R1 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- where R2 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- or a compound of the formula:
- where R5 is selected from one of the substituents described above for R.
A compound of the formula
- where R is
- Where R1 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- where R2 is H or alkyl, cycloalkyl or aryl moiety, free or containing one of a variety of functional groups such as COOH, OH, NH or derivatives thereof;
- or a compound of the formula
- where R5 is selected from one of the substituents described above for R.
A compound as depicted in structure 10.
Dependencies are inferred from the claim text.