US 7,842,719 B2 · Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus

Abstract

The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specifically have efficacy as treatments for hepatitis C viral infections.

Claims3

Dependent claims

A method of treating an infection caused by Flaviviridae sp., comprising the step of administering an effective amount of a sesquiterpene having the formula:

wherein:
X1 and X2 are O;
Y is O;
Z is O, and
Q is selected from the group consisting of CO, CHOH, CHOCH3, CHOC2H5, CHOC3H7, and CHOCOCCH2CH2COOH,
and the pharmaceutically acceptable salts thereof;
and wherein the infection is hepatitis C or bovine viral diarrhea.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/664,008Filed 16 Sep 2003 · us provisional application

Priority

31 Oct 2002

Published

US 2005/0059647 A117 Mar 2005

Granted

30 Nov 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/55
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/335
Heterocyclic compounds: having oxygen as the only ring hetero atom, e.g. fungichromin
A61K 31/553
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine,…
A61K 31/554
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having at least one nitrogen and one sulfur as ring hetero atoms, e.g.…

Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus

Life of this patent

Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus

Life of this patent

Abstract

Claims3