DNT-maleate and methods of preparation thereof
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsSantiago Ini, Anita Liberman, Mili Abramov, Tamas Koltai
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Abstract
(S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation of DNT-maleate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-maleate are provided.
Claims15
A compound (S)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate) having the following formula:
A crystalline form of (S)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamine maleate):
- characterized by a powder XRD pattern with peaks at about 9.4°, 14.0°, 18.7°, 23.3°, and 24.9° 2θ±0.2° 2θ.
A crystalline form of (S)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanaznine maleate):
- characterized by a powder XRD pattern with peaks at about 14.4°, 18.5°, 23.1°, 27.2°, and 31.3° 2θ±0.2° 2θ.
A crystalline form of (S)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamine maleate):
- characterized by a powder XRD pattern with peaks at about 9.4°, 18.7°, 23.4°, and 25.3° 2θ±0.2° 2θ.
Dependencies are inferred from the claim text.