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US 7,842,715 B2Granted
N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists
AssigneeWyeth
InventorsDerek Cecil Cole, Magda Asselin, Joseph Raymond Stock, Jin-In Kim
Life of this patent
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Abstract
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
Claims14
A compound of formula I
- wherein
- X is CO, CH2 or SOm;
- Y is NR6, NR6CO, O or SOp;
- m and p are each individually 0 or an integer of 1 or 2;
- R1 and R2 are taken together with the atom to which they are attached to form an optionally substituted 4- to 7-membered ring optionally containing one or two additional heteroatoms selected from N, O or S
- R3 is an aryl group optionally substituted;
- R4 and R5 are each independently H, halogen, OR9 or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted;
- and
- R6 and R9 are each independently H or an optionally substituted alkyl group;
- or
- a stereoisomer thereof or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.