Fused phenyl amido heterocyclic compounds

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• Ring A is (4-12)-membered heterocyclyl;
• Ring B is a fused benzene ring selected from the group consisting of:
• wherein in each of the above formula B(i) and B(ii), bond a is connecting said ring B fused benzene ring to the group -L2-R2 and bond b is connecting said ring B fused benzene ring to the group >C═O—NH—;
• Each R1 and R4 can be independently bonded to any carbon atom or nitrogen atom of ring C;
• Ring C contains an optional double bond and an optional heteroatom selected from the group consisting of —O—, —NR5—, and —S—;
• each of R1, R1a, and R4 are independently selected from H, halo, cyano, nitro, —CF3, —CHF2, —CH2F, trifluoromethoxy, azido, hydroxy, (C1-C6)alkoxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C═O)—R5, —(C═O)—O—R5, —O—(C═O)—R5, —NR5(C═O)—R7, —(C═O)—NR5R6, —NR5R6, —NR5OR6, —S(O)kNR5R6, —S(O)j(C1-C6)alkyl, —O—SO2—R5, —NR5—S(O)k, —(CR5R6)v(3-10)membered cycloalkyl, —(CR5R6)v(C6-C10aryl), —(CR5R6)v(4-10)-membered heterocyclyl, —(CR5R6)q(C═O)(CR5R6)v(C6-C10)aryl, —(CR5R6)q(C═O)(CR5R6)v(4-10)-membered heterocyclyl, —(CR5R6)vO(CR5R6)q(C6-C10)aryl, —(CR5R6)vO(CR5R6)q(4-10)-membered heterocyclyl, —(CR5R6)qS(O)j (CR5R6)v(C6-C10)aryl, and —(CR5R6)qS(O)j (CR5R6)v(4-10)-membered heterocyclyl;
• or
• R1 and R4, if they are both attached on one carbon atom of the ring C, together optionally form a (3-10)-membered cycloalkyl or (4-10)-membered heterocyclyl ring;
• L2 is >C═O, >C═O—O—, —O—C═O—, —O—C═O—O—, —O—C═O—NR5—, —NR5—(C═O)—, —NR5—(C═O)—O—, —NR5—(C═O)—NR6, —(C═O)—NR5—, —O—, —NR5—, —S(O)j—, —NR5SO2—, —SO2NR5—, —(C═O)NR5SO2—, —SO2NR5(C═O)—, or —CR5R6;
• R2 is H, (C1-C6)alkyl, —(CR5R6)v(3-10)-membered cycloalkyl, —(CR5R6)v(C6-C10aryl), or —(CR5R6)v(4-12)-membered heterocyclyl;
• R3 is H, halo, cyano, nitro, —CF3, —CHF2, —CH2F, trifluoromethoxy, azido, hydroxy, (C1-C6)alkoxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C═O)—R5, —(C═O)—O—R5, —O—(C═O)—R5, —NR5(C═O)—R7, —(C═O)—NR5R6, —NR5R6, —NR5OR6, —S(O)kNR5R6, —S(O)j(C1-C6)alkyl, —O—SO2—R5, —NR5—S(O)k, —(CR5R6)v(3-10)-membered cycloalkyl, —(CR5R6)v(C6-C10aryl), —(CR5R6)v(4-10)-membered heterocyclyl, —(CR5R6)q(C═O)(CR5R6)v(C6-C10)aryl, —(CR5R6)q(C═O)(CR5R6)v(4-10)-membered heterocyclyl, —(CR5R6)vO(CR5R6)q(C6-C10)aryl, —(CR5R6)vO(CR5R6)q(4-10)-membered heterocyclyl, —(CR5R6)qS(O)j(CR5R6)v(C6-C10)aryl, or —(CR5R6)qS(O)j(CR5R6)v(4-10)-membered heterocyclyl;
• each of R5, R6 and R7 are independently selected from H, (C1-C6)alkyl, —(CR8R9)v(3-10)-membered cycloalkyl, —(CR8R9)p(C6-C10)aryl, and —(CR8R9)p(4-10)-membered heterocyclyl;
• any carbon atoms of the (C1-C6)alkyl, the (3-10)-membered cycloalkyl, the (C6-C10)aryl and the (4-10)-membered heterocyclyl of the foregoing R1, R2, R3, R4, R5, R6 and R7 are independently optionally substituted with 1 to 3 R11 substituents each independently selected from halo, cyano, nitro, —CF3, —CHF2, —CH2F, trifluoromethoxy, azido, hydroxy, —O—R12, (C1-C6)alkoxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C═O)—R8, —(C═O)—R12, —(C═O)—O—R8, —(C═O)—O—R12, —O—(C═O)—R8, —O—(C═O)—R12, —NR8(C═O)—R10, —(C═O)—NR8R9, —(C═O)—NR8R12, —NR8R9, —NR8R12, —NR8OR9, —NR8OR12, —S(O)kNR8R9, —S(O)kNR8R12, —S(O)j(C1-C6)alkyl, —S(O)jR12, —O—SO2—R8, —O—SO2—R12, —NR8—S(O)k, —NR12—S(O)k, —(CR8R9)v(3-10)-membered cycloalkyl, —(CR8R9)v(C6-C10aryl), —(CR8R9)v(4-10)-membered heterocyclyl, —(CR8R9)q(C═O)(CR8R9)v(C6-C10)aryl, —(CR8R9)q(C═O)(CR8R9)v(4-10)-membered heterocyclyl, —(CR8R9)vO(CR8R9)q(C6-C10)aryl, —(CR8R9)vO(CR8R9)q(4-10)-membered heterocyclyl, —(CR8R9)qS(O)j(CR8R9)v(C6-C10)aryl, and —(CR8R9)qS(O)j(CR8R9)v(4-10)-membered heterocyclyl;
• any carbon atoms of the (C1-C6)alkyl, the (3-10)-membered cycloalkyl, the (C6-C10)aryl and the (4-10)-membered heterocyclyl of the foregoing R11 are independently optionally substituted with 1 to 3 R13 substituents each independently selected from halo, cyano, nitro, —CF3, —CHF2, —CH2F, trifluoromethoxy, azido, (CH2)vOH, (C1-C6)alkoxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C═O)—R8, —(C═O)—R12, —(C═O)—O—R8, —(C═O)—O—R12, —O—(C═O)—R8, —O—(C═O)—R12, —NR8(C═O)—R10, —(C═O)—NR8R9, —NR8R9, and —NR8R12;
• any nitrogen atoms of the (4-10)-membered heterocyclyl of the foregoing R1, R2, R3, R4, R5, R6, R7, R11 and R12 are independently optionally substituted with (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C═O)—R8, —(C═O)—O—R8, —(C═O)—NR8R9, —(CR8R9)v(3-10)-membered cycloalkyl, —(CR8R9)v(C6-C10aryl), —(CR8R9)v(4-10)-membered heterocyclyl, —(CR8R9)q(C═O)(CR8R9)v(C6-C10)aryl, or —(CR8R9)q(C═O)(CR8R9)v(4-10)-membered heterocyclyl;
• each R8, R9, and R10 are independently H or (C1-C6)alkyl;
• R12 is —(CR8R9)v(3-10)-membered cycloalkyl, —(CR8R9)v(C6-C10aryl), or —(CR8R9)v(4-10)-membered heterocyclyl;
• p, q, and v are each independently 0, 1, 2, 3, 4, or 5;
• w, n and j are each independently 0, 1, or 2;
• k is 1 or 2;
• and
• t and z are each independently 1, 2, 3, or 4;
• with the proviso that when compound (I) has the formula:
• wherein
• Ring A is pyridin-2-yl or thiazol-2-yl;
• L2 is —O—;
• and
• R2 is (C1-C6)alkyl, —(CR5R6)v(3-10)-membered cycloalkyl, —(CR5R6)v(C6-C10aryl), or —(CR5R6)v(4-12)-membered heterocyclyl;
• then
• R2 is further substituted by R11 substituents each independently selected from —SO2—(C1-C6)alkyl, —S(O)jR12, —S(O)kNR8R9, —S(O)kNR8R12, —(C═O)—R12, —(C═O)—NR8R9, and —(C═O)—NR8R12.