Substituted benzofused derivatives and their use as vanilloid receptor ligands
AssigneeGlenmark Pharmaceuticals S.A.
InventorsLaxmikant Atmaram Gharat, Uday Mukund Joshi, Neelima Khairatkar-Joshi, Suresh Mahadev Kadam
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Abstract
The present invention relates to substituted benzofused derivatives, which can be used as vanilloid receptor ligands, method of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
Claims40
The compound (±) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof.
The compound (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof.
The compound (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea hydrochloride.
The compound (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea sulfate.
A pharmaceutical composition comprising (±) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
The compound 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(isoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
The compound (±) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(2-oxoisoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof.
The compound (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(2-oxoisoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising (±) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(2-oxoisoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising (+) 1-(3,4-dihydro-spiro-[2H-1-benzopyran-2,1′-cyclobutane]-4-yl)-3-(2-oxoisoquinolin-5-yl)urea, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.