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US 7,842,700 B2Granted
Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride, production method thereof and use thereof
AssigneeAjinomoto Co., Inc.
InventorsKoichi Fujita, Shinichiro Takahashi, Tatsuya Okuzumi, Tatsuhiro Yamada, Kotaro Okado, Noriyasu Kataoka, Haruko Hirashima, Hideyuki Yamaguchi
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Abstract
Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride are useful as α4 integrin inhibitors.
Claims15
A crystal of the hydrochloride salt of the compound of formula (I):
- which is either:
- crystal form Cl 1, which has peaks at the diffraction angles (2θ) 2.9°, 7.7°, 11.6°, and 20.3° in its powder X-ray diffraction pattern;
- crystal form Cl 2, which has peaks at the diffraction angles (2θ) 8.5°, 10.5°, 16.0°, 17.0°, and 23.6° in its powder X-ray diffraction pattern;
- crystal form Cl 3, which has peaks at the diffraction angles (2θ) 3.6°, 8.9°, and 12.4° in its powder X-ray diffraction pattern;
- crystal form Cl 4, which has peaks at the diffraction angles (2θ) 4.9° and 17.5° in its powder X-ray diffraction pattern;
- or
- crystal form Cl 5, which has peaks at the diffraction angles (2θ) 8.2°, 11.2°, 14.3°, and 15.6° in its powder X-ray diffraction pattern.
4 more elements
Dependencies are inferred from the claim text.