Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors

A pyridine methylene azolidinone compound according to Formula (I),

• wherein
• R1 is selected from the group consisting of H, a halogen, a C1-C6-alkyl group, a C2-C6-alkenyl group, a C2-C6-alkynyl group, a C1-C6-alkyl group having an alkoxy substituent, an alkoxycarbonyl group, an acyl group, a sulfonyl group, a sulfanyl group, a sulfinyl group, an alkoxy group, and an amino group;
• R2 is selected from the group consisting of H, a halogen, a C1-C6-alkyl group, a C2-C6-alkenyl group, a C2-C6-alkynyl group, an aryl group, a heteroaryl group, a C3-C8-cycloalkyl group, a C3-C8-heterocycloalkyl group, an aryl C1-C6-alkyl group, a heteroaryl C1-C6-alkyl group, a C3-C8-cycloalkyl C1-C6-alkyl group, a C3-C8-heterocycloalkyl C1-C6-alkyl group, a C1-C6-alkyl alkoxy group, an alkoxycarbonyl group, an acyl group, a sulfonyl group, a sulfanyl group, a sulfinyl group, an alkoxy group and an amino group;
• X is selected from the group consisting of S, NH and O;
• Y is selected from the group consisting of O, S and NR3, wherein R3 is selected from the group consisting of H, a C1-C6-alkoxy group, a substituted C1-C6-alkoxy group, a C1-C6-alkyl group, a substituted C1-C6-alkyl group, a C2-C6-alkenyl group, a substituted C2-C6-alkenyl group, a C2-C6-alkynyl group, a substituted C2-C6-alkynyl group, a C1-C6-alkyl aryl group, a substituted C1-C6-alkyl aryl group, a cyano group, a sulfonyl group, and a substituted sulfonyl group;
• A together with the pyridine ring forms a group represented by formula (Ia):
• n is 1 or 2;
• or pharmaceutically acceptable salts thereof.