Substituted piperazines

A compound having the formula:

• wherein the subscript m is 0 to 1;
• R1 is C1-4 alkyl;
• R2a, R2b, R2c, R2d and R2e are each members independently selected from the group consisting of hydrogen, halogen, —ORc, —NRcRd, —SRc, —Re, —CN, —NO2, —CO2Rc, —CONRcRd, —C(O)Rc, —OC(O)NRcRd, —NRdC(O)Rc, —NRdC(O)2Re, —NRc—C(O)NRcRd, —S(O)Re, —S(O)Re, —NRcS(O)2Re, —S(O)2NRcRd, —N3, —X2ORc, —O—X2ORc, —X2NRcRd, —O—X2NRcRd, wherein X2 is C1-4 alkylene, and each Rc and Rd is independently selected from hydrogen, C1-8 alkyl, C1-8 haloalkyl, and C3-6 cycloalkyl, or optionally Rc and Rd when attached to the same nitrogen atom can be combined with the nitrogen atom to form a five or six-membered ring having from 0 to 1 additional heteroatoms selected from N and O as ring members;
• and each Re is independently selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, and C3-6 cycloalkyl, such that at least one of R2a, R2b, R2c, R2d and R2e is other than H;
• R3a, R3b and R3c are each members independently selected from the group consisting of hydrogen, halogen, —ORf, —NRfRg, —SRf, —Rh, —CN, —NO2, —CO2Rf, —CONRfRg, —C(O)Rf, —X3ORf, —X3OC(O)Rf, —X3NRfRg, —X3SRf, —X3CN, —X3NO2, —X3CO2Rf, —X3CONRfRg, —X3C(O)Rf, —X3NRgC(O)Rf, —X3NRgC(O)2Rh, —X3NRf—C(O)NRfRg, —Y, —X3Y, and —X3N3, wherein Y is selected from the group consisting of furanyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, triazolyl, tetrazolyl and oxadiazolyl, optionally substituted with from one to three substituents selected from the group consisting of halogen, —ORf, and —Rh, and wherein each X3 is independently C1-4 alkylene, and each Rf and Rg is independently selected from hydrogen, C1-8 alkyl, C1-8 haloalkyl, and C3-6 cycloalkyl, or when attached to the same nitrogen atom can be combined with the nitrogen atom to form a five or six-membered ring having from 0 to 1 additional heteroatoms selected from N and O as ring members, and each Rh is independently selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, and C3-6 cycloalkyl, wherein at least one of R3a, R3b and R3c is selected from the group consisting of —Y and —X3—Y, and wherein at least one of R3a, R3b and R3c is selected from the group consisting of halogen, C1-4alkyl and C1-4haloalkyl.