Organic compounds

A compound of the formula (I)

• where
• R1 is substituted or unsubstituted dihydro-2H-benzo[1,4]oxazinyl;
• R2 is phenyl substituted by 1-3 halogen, hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, halo-C1-6-alkyl, hydroxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, cyano-C1-6-alkyl, carboxy-C1-6-alkyl, C1-6-alkanoyloxy-C1-6-alkyl, C1-6-alkoxycarbonyloxy-C1-6-alkyl, C1-6-alkoxycarbonyl, or C1-6-alkoxy groups, or a C1-6-alkylenedioxy group, and/or by an L1-T1-L2-T2-L3-T3-L4-T4-L5-U radical;
• L1, L2, L3, L4 and L5 are each independently a bond, C1-8-alkylene, C2-8-alkenylene or C2-8-alkynylene, or are absent;
• T1, T2, T3 and T4 are each independently
• (a) a bond, or are absent, or are one of the groups
• (b) —CH(OH)—
• (c) —CH(OR6)—
• (d) —CH(NR5R6)—
• (e) —CO—
• (f) —CR7R8—
• (g) —O— or —NR6—
• (h) —S(O)0-2—
• (I) —SO2NR6—
• (j) —NR6SO2—
• (k) —CONR6—
• (l) —NR6CO—
• (m) —O—CO—
• (n) —CO—O—
• (o) —O—CO—O—
• (p) —O—CO—NR6—
• (q) —N(R6)—CO—N(R6)—
• (r) —N(R6)—CO—O—
• (s) pyrrolidinylene, piperidinylene or piperazinylene
• (t) —C(R11)(R12)—,
• where the bonds starting from (b)-(t) lead to a saturated or aromatic carbon atom of the adjacent group if the bond starts from a heteroatom, and where not more than two (b)-(f) groups, three (g)-(h) groups and one (i)-(t) group are present;
• R3 is hydroxyl, C1-6-alkoxy or C2-6-alkenyloxy;
• R4 is hydrogen;
• R5 and R6 are each independently hydrogen, C1-6-alkyl, C2-6-alkenyl, aryl-C1-6-alkyl or acyl, or, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered heterocyclic ring which may contain an additional nitrogen, oxygen or sulphur atom or a —SO— or —SO2— group, and the additional nitrogen atom may optionally be substituted by C1-6-alkyl radicals;
• R7 and R8, together with the carbon atom to which they are bonded, are a 3-7-membered ring which may contain one or two —O— or —S— atoms or —SO— or —SO2— groups;
• R9 is hydrogen, C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, acyl or arylalkyl;
• R10 is carboxyalkyl, alkoxycarbonylalkyl, alkyl or hydrogen;
• R11 is hydrogen or C1-6-alkyl;
• R12 is hydrogen or C1-6-alkyl;
• U is hydrogen, C1-6-alkyl, C3-8-cycloalkyl, cyano, optionally substituted C3-8-cycloalkyl, aryl, or heterocyclyl;
• Q is absent;
• X is a bond, oxygen or sulphur, or is a >CH—R11, >CHOR9, —O—CO—, >CO, >C═NOR10, —O—CHR11— or —O—CHR11—CO—NR9— group and the bond starting from an oxygen or sulphur atom leads to a saturated carbon atom of the Z group or to R1;
• W is oxygen or sulphur;
• Z is C1-6-alkylene, C2-6-alkenylene, hydroxy-C1-6-alkylidene, —O—, —S—, —O-alk-, —S-alk-, -alk-O—, -alk-S— or -alk-NR9—, where alk is C1-6-alkylene;
• and where
• (a) if Z is —O— or —S—, X is >CH—R11 and either R2 contains an L1-T1-L2-T2-L3-T3-L4-T4-L5-U substituent or R4 is a substituent other than hydrogen as defined above;
• (b) if Z is —O-alk- or —S-alk-, X is >CH—R11;
• and
• (c) if X is a bond, Z is C2-6-alkenylene, -alk-O— or -alk-S—,
• n is 0 or 1;
• m is 0;
• or a pharmaceutically acceptable salt thereof.